Does Depo-Provera provide protection against sexually transmitted infections (STIs)?

Depo-Provera is a hormonal contraceptive that is effective in preventing pregnancy, but it does not offer protection against sexually transmitted infections (STIs). This is because Depo-Provera functions by inhibiting ovulation and altering the menstrual cycle rather than providing a physical barrier to pathogens. The only contraceptives that offer protection against STIs are barrier methods, such as condoms. Therefore, the assertion that Depo-Provera does not protect against STIs is accurate, making this response correct.

In contrast, the other choices either imply that some form of protection is offered, which is not true, or suggest conditional protection based on usage, which does not align with the known facts about how this contraceptive works.